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entpolarisieren depolarize
entpolarisieren to depolarize
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A Novel Role for Connexin Hemichannel in Oxidative Stress and Smoking-Induced Cell Injury: ... stress is linked to many pathological conditions, including ischemia, atherosclerosis and neurodegenerative disorders. The molecular mechanisms of oxidative stress induced pathophysiology and cell death are currently poorly understood. Our present work demonstrates that oxidative stress induced by reactive oxygen species and cigarette smoke extract depolarize the cell membrane and ...

Srinivasan Ramachandran et al.

PLoS ONE , 08 Aug 2007

Higher Sensitivity of Human Auditory Nerve Fibers to Positive Electrical Currents: ... of a pulse can depolarize the nerve fibers and ...

Olivier Macherey et al.

Journal of the Association for Research in Otolaryngology , 01 Jun 2008

Mitochondrial Ca 2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs: ... and R-flurbiprofen depolarize mitochondria and ...

Sara Sanz-Blasco et al.

PLoS ONE , 23 Jul 2008

Swelling-Activated Ca 2+ Channels Trigger Ca 2+ Signals in Merkel Cells: ... cells are proposed to be mechanosensory cells that signal afferents via neurotransmission; however, functional studies testing this hypothesis in intact skin have produced conflicting results. To test this model in a simplified system, we asked whether purified Merkel cells are directly activated by mechanical stimulation. Cell shape was manipulated with anisotonic solution changes and responses were monitored by Ca 2+ imaging with fura-2. We found that hypotonic-induced cell swelling, but not hypertonic solutions, triggered cytoplasmic Ca 2+ transients. Several lines of evidence indicate that these signals arise from swelling-activated Ca 2+ -permeable ion channels. First, transients were reversibly abolished by chelating extracellular Ca 2+ , demonstrating a requirement for Ca 2+ influx across the plasma membrane. Second, Ca 2+ transients were initially observed near the plasma membrane in cytoplasmic processes. Third, voltage-activated Ca 2+ channel (VACC) antagonists reduced transients by half, suggesting that swelling-activated channels depolarize plasma membranes to ...

Henry Haeberle et al.

PLoS ONE , 12 Mrz 2008