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Definition
 
enEnglisch
Extracellular Matrix Binding Pathway Definition: Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression, leading to cell shape changes during cell spreading or migration. Epithelial cells respond to extracellular matrix (ECM) causing integrin-mediated FAK phosphorylation; this, in turn, phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to signal amplification. FAK also binds PI-3 kinase and acts upstream in the MAP kinase pathway. When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked. Src phosphorylates p190RhoGAP, inactivating its GAP function and allowing RhoGTP to stay active longer, promoting further signal amplification. Activated RhoGTP binds to downstream kinases such as Rho-associated coiled coil-containing protein kinase (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other signal transduction events. (Biocarta)
PRN Definition: As needed. (NCI)
As Necessary Definition: As needed, usually referring to the timing of the administration of a treatment or medication.
necessary Definition: [1] erforderlich, notwendig, nötig haben
 
 
deDeutsch
notwendig Definition: [1] unter allen Umständen erforderlich [2] in der Konsequenz unvermeidbar
nötig Definition: [1] dringend erforderlich, nicht entbehrlich
unumgänglich Definition: [1] nicht zu umgehen, unausweichlich, absolut notwendig, absolut erforderlich
vonnöten Definition: [1] für einen bestimmten Zweck zwingend, nachdrücklich geboten, nötig
erforderlich Definition: [1] jemand/etwas ist nötig, wird gebraucht
not Definition: [1] selten, veraltend: notwendig, nötig
 
frFranzösisch
requis Definition: Personne contrainte à effectuer une tâche par les autorités lors d’une guerre.