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CDC91L1 Gene Definition: This gene is involved in the regulation of cell division.
GPI Transamidase Component PIGU Definition: Ubiquitously expressed by human CDC91L1 Gene (PIGU Family), conserved 435-aa 50-kD GPI Transamidase Component PIGU is an integral ER membrane protein containing 9 putative transmembrane domains, with similarity to Cdc91 (S. cerevisiae), and a critical subunit of the GPI transamidase complex (PIGU, PIGK/GPI8, PIGS, PIGT, and GPAA1/GAA1) that attaches posttranslational GPI-anchors to the C-termini of cell surface proteins attached to membranes via GPI. PIGU may be involved in recognition of the GPI attachment signal or the lipid portion of GPI. (NCI)
CDC91L1 wt Allele Definition: Human CDC91L1 wild-type allele is located in the vicinity of 20q11.22 and is approximately 117 kb in length. This allele, which encodes GPI transamidase component PIG-U protein, plays a role in glycosylphosphatidylinositol (GPI) anchor biosynthesis.