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Despite a usually normal or high cardiac output, severe sepsis is associated with inadequate tissue oxygenation, leading to organ failure and death.

Jean-Louis Vincent

Critical Care 7 (4), 2003

Hence, despite a normal or high cardiac output, severe sepsis and septic shock are characterized by an inadequate organ oxygenation, leading ultimately to multiple organ failure and death.

Jean-Louis Vincent

Critical Care 7 (4), 2003

Almost 20 years ago, Abraham and colleagues [ 1 ] noted that survivors from septic shock had significantly higher cardiac indexes prior to the shock episode than did nonsurvivors, leading to the suggestion that pushing patients to reach high and even 'supranormal' levels of cardiac output could be beneficial.

Jean-Louis Vincent

Critical Care 7 (4), 2003

There is little doubt that, in certain patients, achieving and maintaining high levels of cardiac output is associated with improved outcomes; the difficulty lies in identifying those patients.

Jean-Louis Vincent

Critical Care 7 (4), 2003

What is the rationale for maintaining high cardiac output?

Vinay K Sharma et al.

Critical Care 7 (4), 2003

Adequate vascular pressure versus high cardiac output in septic patients MAP and systemic vascular resistance have been shown to be determinants of mortality in patients with septic shock.

Vinay K Sharma et al.

Critical Care 7 (4), 2003

Table 1 Randomized controlled trials of high cardiac output in patients with sepsis

Vinay K Sharma et al.

Critical Care 7 (4), 2003

Use of terlipressin, an analogue of vasopressin, can be considered in septic shock patients with intractable hypotension and high cardiac output in whom fluid resuscitation and high-dose conventional catecholamines have failed.

Marc Leone et al.

Critical Care 10 (2), 2006

In animal experiments it could be shown, however, that despite a lowered CVP, which depended on the elevated body temperatures, a high cardiac output (CO), as well as an elevated stroke volume could be maintained.

K. A. Kirsch et al.

The Yale Journal of Biology and Medicine 59 (3), 1986

Conversely, a high cardiac output value is more difficult to rely on in absolute terms.

Jésus Gonzalez et al.

Critical Care 7 (2), 2003

Conversely, there are marked discrepancies between the two approaches for high cardiac output values.

Jésus Gonzalez et al.

Critical Care 7 (2), 2003

High cardiac output values should thus be treated and used cautiously.

Jésus Gonzalez et al.

Critical Care 7 (2), 2003

This is novel information • Conversely, the divergence between methods for high cardiac output values prompts caution in the presence of such results

Jésus Gonzalez et al.

Critical Care 7 (2), 2003

This consists of hypervolaemia and a high cardiac output (hyperkinesis) with tissue hyperperfusion.

Jan Brod

The Ulster Medical Journal 54 (Suppl), 01 Aug 1985